Polynucleotide Eye Treatment
What Is a Polynucleotide Eye Treatment?
The Under-Eye Treatment That Regenerates Rather Than Fills
A polynucleotide eye treatment is a regenerative injectable therapy using PDRN (polydeoxyribonucleotide) purified DNA fragments to repair and rejuvenate the delicate periorbital tissue of the under-eye area. Unlike dermal filler, which adds external volume, polynucleotides instruct the skin’s own cells to regenerate themselves producing genuine tissue improvement rather than an artificial correction.
At Faceit by Ian in Walton-on-Thames, Ian uses Ami Plus a high-quality professional polynucleotide product with a strong tissue regenerating effect. Ami Plus has an excellent profile for repairing damage to the dermis, stimulating collagen and elastin, improving microcirculation and delivering strong hydration and rejuvenation to the delicate under-eye tissue.
A course of 3 sessions is required for best results, spaced 3–4 weeks apart. Results develop progressively as the PDRN-triggered tissue regeneration takes effect over 2–4 weeks following each session.
The Product Ian Uses
Ami Plus - Professional PDRN for Under-Eye Regeneration
Ian uses Ami Plus – a high-quality professional polynucleotide product specifically formulated for aesthetic injectable use in delicate areas. Ami Plus delivers a strong tissue regenerating effect via PDRN that repairs damage to the dermis, provides strong hydration and rejuvenation and produces visible reduction of dark circles and skin fatigue symptoms.
- High-purity PDRN with strong tissue regenerating effect
- Specifically designed for delicate periorbital use
- Repairs dermal damage and stimulates collagen
- Strong hydration and rejuvenation of under-eye tissue
- Reduces skin blueing and fatigue-related discolouration
- Biocompatible — exceptional safety profile
The Clinical Science
How PDRN Regenerates Under-Eye Tissue
Polynucleotide PDRN treatment produces results through four simultaneous biological mechanisms – all triggered by the same PDRN molecules injected into the under-eye dermis.
Fibroblast Proliferation
PDRN activates adenosine A2A receptors on fibroblasts, triggering cellular proliferation and stimulating these collagen-producing cells to multiply and become more active directly increasing the rate at which new collagen and elastin are synthesised in the treated area.
Neocollagenesis & Elastin Synthesis
The stimulated fibroblasts produce new Type I and Type III collagen and elastin fibres in the under-eye dermis. Over a course of treatments, this progressively thickens the delicate periorbital skin making it less translucent, more resilient and visibly firmer.
Angiogenesis (New Vessel Formation)
PDRN supports the formation of new blood vessels in the treated tissue, improving local circulation and cellular nutrition. This is particularly significant for vascular dark circles improved microcirculation in the under-eye area reduces the pooling of deoxygenated blood that creates the bluish discolouration.
Anti-inflammatory Modulation
PDRN modulates local inflammatory processes in the under-eye tissue, reducing chronic low-grade inflammation that contributes to puffiness, discolouration and poor tissue quality. This anti-inflammatory effect produces the visible reduction in "skin blueing" and fatigue appearance that clients notice post-treatment.
Polynucleotide Eye Treatment - FAQs
The under-eye area is sensitive but most clients report the sensation as manageable — a brief sharp feeling at each injection point. Ian uses ultra-fine needles and professional technique to minimise discomfort. Topical numbing cream can be applied beforehand if preferred. The session typically takes 20–30 minutes in total.
PDRN (polydeoxyribonucleotide) is a highly purified DNA fragment derived from salmon sperm cells, with all immunogenic components removed to ensure it is biocompatible with human tissue. It is one of the most extensively researched biostimulatory compounds in regenerative medicine, with a well-established safety record and multiple clinical studies demonstrating its tissue regeneration effects.
Yes — polynucleotide eye treatment is commonly combined with Profhilo, skin boosters or microneedling as part of a comprehensive skin rejuvenation programme. Ian advises on the optimal combination and timing for your specific goals at your first consultation. Combining polynucleotide eye treatment with full-face polynucleotide treatment on the same day is also possible.
Because PDRN (polydeoxyribonucleotide) the active component of polynucleotide treatments — is derived from highly purified salmon sperm DNA. This is why some clients refer to the treatment as salmon DNA under-eye treatment or salmon PDRN eye injection. The term “polynucleotide” is the correct clinical terminology; “salmon DNA” is the informal description of its source.
The eye treatment uses Ami Plus specifically targeted at the delicate periorbital area — the under-eye zone — with ultra-fine needle technique appropriate for this particularly thin-skinned area. Ian also offers full-face polynucleotide treatment (PN facial) across a broader periorbital and facial area, which can be combined with or carried out separately from the dedicated eye treatment.
Polynucleotide eye treatment (PDRN) using Ami Plus is available at Faceit by Ian, Studio 35, Walton Business Centre, Walton-on-Thames, Surrey KT12 2SD. £105 per session. Course of 3 recommended. Ian serves clients from Weybridge, Esher, Cobham, Kingston upon Thames, Richmond and across South West London.